Starting with a narrative that tells how the Olympians managed to seize the throne of power from the hands of the Titans, and how the three brothers ruler of the gods, Zeus (Liam Neeson), Poseidon (Danny Huston) and Hades (Ralph Fiennes), finally away from each other , Clash of the Titans then described how Perseus was found floating on a sea by a fisherman, Spyros (Pete Postlethwaite). Spyros Perseus finally decided to bring home and care for her.
Growing up, Perseus (Sam Wothington) are now widely helping his family and following in the footsteps Spyros as a fisherman. Unfortunately, Spyro family happiness did not last long when they were all killed as a result of raging Agros Hades attacking troops are being expressed their opposition to the gods to tear down the statue of Zeus. Alone, Perseus eventually rescued by troops Agros and bring him into the kingdom.
Agros kingdom itself when it was hit by a lot of problems when the kings and their queens, Cepheus (Vincent Regan) and Cassiopeia (Polly Walker), led a resistance against the gods, who make the gods, especially Zeus, became angry. Zeus eventually sends Hades to give the message that if the whole kingdom Agros want to survive, then they have to sacrifice the princess Andromeda (Alexa Davalos) to the Kraken, a monster created by Hades, within 10 days.